Hair loss and Regrowth

How minoxidil stimulates hair regrowth remains undetermined. Biopsies in androgenetic alopecia (male pattern hair loss ) demostrate the primary morphologic event in male pattern hair loss is miniaturization of terminal hair follicles, shortening of the hair regrowth cycle.

J Allergy Clin Immunol. 2009;123(:1355.

Risk analysis of early childhood eczema.
Bisgaard H, et al

BACKGROUND: The increasing prevalence of eczema suggests the role of environmental factors triggering a genetic predisposition. OBJECTIVE: To analyze the effect of environmental exposures in early life and genetic predisposition on the development of eczema before age 3 years. METHODS: The Copenhagen Study on Asthma in Childhood is a prospective clinical study of a birth cohort of 411 children born of mothers with asthma. Eczema was diagnosed, treated, and monitored at the clinical research unit, and complete follow-up for the first 3 years of life was available for 356 children. Risk assessments included filaggrin loss-of-function mutation; parent’s atopic disease; sex; social status; previous deliveries; third trimester complications and exposures; anthropometrics at birth; month of birth; duration solely breast-fed; introduction of egg, cow’s milk, and fish; time spent in day care; cat and dog at home; feather pillow; nicotine in infant’s hair; and temperature and humidity in bedroom. RESULTS: Eczema developed in 43.5% of the infants. CONCLUSIONS: Dog exposure reduced the risk of eczema, whereas short length at birth, filaggrin mutation, and parental atopy increased the risk of eczema by age 3 years.

edited for hairnloss blog

Not technically related to hair loss treatment. But here is Dr Proctor’s organic semiconductor device in the Smithsonian institution’s “Smithsonian chips” collection.

Z Hautkr. 1977 Nov 15;52(22):1129-34.

Alopecia areata: successful half-side treatment with DNCB

Happle R, Echternacht K.

edited for hair loss blog

In 46 patients with hair loss due to alopecia areata, one side of the head was treated with weekly applications of DNCB, dissolved in acetone. The therapeutic aim was mild contact dermatitis. The other side of the head served as control region. A therapeutic effect was noted in 36 patients: 22 patients showed regrowth of hair exclusively on the treated side, and in 14 patients hair regrowth was considerably faster and more dense on the treated side. In 8 patients no regrowth was observed, and in 2 patients regrowth occurred on both sides without any difference of intensity. The difference between both sides with regard to hair growth was seen in all of the 7 patients with moderate involvement and in 12 out of 13 patients with extensive involvement; but also in 17 out of 26 patients with alopecia areata totalis or fere totalis. The difference was noted, in the majority of cases, within 3 months. These results prove the efficacy of DNCB treatment of alopecia areata.